As a compounder, we constantly explore various medications’ values in multiple disease states, not just the indicated usage. Off-label use is the creative field of pharmacy where we can expand our collective ability to solve patient problems, and then share the solutions with one another.
Traditionally, naltrexone is indicated for the treatment of: alcohol dependence behavior modification, opioid dependence cessation programs, and rapid detoxification from opiate overdose.
Research into the interaction of naltrexone with TLR-4, a receptor found throughout the body, has allowed for the novel use of naltrexone as adjunct therapy for depression, chronic neuropathic pain and gambling behavior modification. Additionally, it is now thought to be the mechanism of action to downregulate inflammation in the brain, leading to use for patients with autism and patients with chronic neuropathic pain hypersensitivity. Low Dose Naltrexone is also considered for the following disease states:
- Multiple sclerosis (MS)
- All auto-immune diseases
- Ulcerative Colitis
- Irritable bowel syndrome (IBS)
Because of these immunomodulatory effects, it is being looked at for arthritis sufferers. It also has a profound effect on both wound healing (positive) and scar formation (preventing hypertrophy).
Talk to the pharmacists at Shertech today to learn more about how LDN- low dose naltrexone- can benefit you.
Literature provided by PCCA* Citations available upon request.